Creating a new non-hormonal contraceptive using anti-sperm antibodies

Development of an ultrapotent anti-sperm antibody construct for non-hormonal contraception

['FUNDING_OTHER'] · MUCOMMUNE, LLC · NIH-11063679

This study is exploring a new, easy-to-use birth control method that involves a ring you place inside your vagina, which releases a special antibody to help stop sperm from reaching an egg, giving you more control without the need for daily pills or timing.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorMUCOMMUNE, LLC (nih funded)
Locations1 site (Morrisville, UNITED STATES)
Trial IDNIH-11063679 on ClinicalTrials.gov

What this research studies

This research aims to develop a non-hormonal contraceptive method that utilizes an intravaginal ring to release an anti-sperm antibody. This antibody works by agglutinating and trapping sperm in mucus, preventing them from reaching the egg. The approach is designed to provide a user-controlled contraceptive option that does not require daily dosing or timing with intercourse. The research builds on previous studies that demonstrated the effectiveness of anti-sperm antibodies in reducing sperm motility.

Who could benefit from this research

Good fit: Ideal candidates for this research are women seeking non-hormonal contraceptive methods who may have concerns about hormonal side effects.

Not a fit: Patients who are not interested in contraceptive methods or those who prefer hormonal options may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide women with a safe and effective non-hormonal contraceptive option.

How similar studies have performed: Previous research has shown success with anti-sperm antibodies in reducing sperm motility, indicating potential for this novel approach.

Where this research is happening

Morrisville, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.