Creating a new mouse population to better understand human genetic diversity
Official title: A Novel Wild-derived Diversity Mouse Population for Precision Mapping and Systems Genetics
Funded at Jackson Laboratory · NIH-11094595 · Data updated 2026-11-12
This study is creating a new type of mouse that has a wider variety of genes, similar to humans, to help researchers better understand how our genes affect health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | April 15, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $718,404 |
| NIH project number | 1R24OD038108-01 |
| Project ID | NIH-11094595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with genetic conditions that are poorly understood or inadequately modeled by current mouse models.
✕Less likely to help
Patients with conditions that are well-represented by existing inbred mouse models may not see significant benefits from this research.
What this research studies
This research focuses on developing a new population of mice that better represents the genetic diversity found in humans. By using wild-derived inbred strains, the study aims to create a mouse model that can capture a wider range of genetic variations and phenotypic responses. This approach will help improve the translation of findings from mouse models to human clinical outcomes, ultimately enhancing our understanding of genetic influences on health and disease. The research involves breeding these mice and analyzing their genetic makeup to identify important variants.
Why it matters
Potential benefit: If successful, this research could lead to more accurate models for studying human diseases and developing targeted treatments.
How similar studies have gone: Previous research has shown that using genetically diverse mouse populations can improve the understanding of complex human diseases, indicating that this approach has potential for success.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Dumont, Bethany L — Jackson Laboratory
- Study coordinator: Dumont, Bethany L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.