Creating a new mouse model to study brown fat function
Official title: A validated mouse model of brown fat targeting
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10809155 · Data updated 2026-11-12
This study is creating a special mouse that helps scientists see and understand how brown fat works in the body, which could lead to better treatments for conditions like obesity and diabetes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $240,750 |
| NIH project number | 1R21OD034470-01A1 |
| Project ID | NIH-10809155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with metabolic disorders or conditions related to obesity and energy regulation.
✕Less likely to help
Patients who do not have metabolic disorders or are not affected by brown fat-related conditions may not receive any benefit from this research.
What this research studies
This research focuses on developing a new mouse model that targets brown adipose tissue, which plays a crucial role in regulating metabolism and energy balance. By using advanced CRISPR/Cas9 technology, the researchers aim to insert a specific genetic marker into a safe location in the mouse genome, allowing for precise tracking of brown fat cells. This model will help scientists better understand the role of brown fat in various physiological processes and could lead to advancements in treatments for metabolic disorders. The research will also validate the new model to ensure its effectiveness and safety for broader scientific use.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for metabolic diseases related to brown fat dysfunction.
How similar studies have gone: Other research using CRISPR technology for genetic modifications in animal models has shown promising results, indicating a potential for success in this novel approach.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Sanchez-Gurmaches, Juan — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Sanchez-Gurmaches, Juan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.