Creating a new mouse model to study age-related eye disease
A Novel Mouse Model for Spontaneous and Age-Related Choroidal Neovascularization
This study is creating a special mouse model to help researchers understand and find better treatments for wet age-related macular degeneration (AMD), a condition that can cause vision loss.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10988984 on NIH RePORTER |
What this research studies
This research focuses on developing a novel mouse model that mimics age-related choroidal neovascularization (CNV), a condition linked to wet age-related macular degeneration (AMD) which can lead to blindness. By introducing specific genetic changes and environmental stressors, the researchers aim to replicate the conditions that contribute to CNV in humans. This model will allow for the testing of new therapies aimed at providing long-term benefits for patients suffering from AMD. The ultimate goal is to better understand the disease mechanisms and develop effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for age-related macular degeneration or those experiencing early signs of the disease.
Not a fit: Patients with other forms of vision impairment unrelated to age-related macular degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that provide long-term relief from age-related macular degeneration.
How similar studies have performed: Other research has shown promise in using animal models to study age-related eye diseases, indicating that this approach has potential for success.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Fong, Guo-Hua — University of Connecticut Sch of Med/dnt
- Study coordinator: Fong, Guo-Hua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.