Creating a new mouse model to improve predictions of human immune responses to flu vaccines
New mouse model to better predict human immunity to influenza vaccination and infection
This study is creating a new type of mouse that acts more like humans when it comes to fighting the flu, so researchers can find better and safer flu vaccines that work well for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10898754 on NIH RePORTER |
What this research studies
This research aims to develop a new mouse model that better mimics human immune responses to influenza vaccination and infection. By using genetically diverse mice and exposing them to various pathogens, the researchers hope to identify more effective vaccine strategies. The study will involve rigorous testing of vaccine candidates to evaluate their safety and ability to generate a strong immune response. This approach could lead to improved flu vaccines that are more effective in humans.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals who are at high risk for influenza, such as the elderly, young children, and those with compromised immune systems.
Not a fit: Patients who are not at risk for influenza or those who have already received effective vaccination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective influenza vaccines, reducing the incidence and severity of flu infections in the population.
How similar studies have performed: Previous research has shown that using diverse animal models can lead to better predictions of human immune responses, suggesting that this approach has potential for success.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Masopust, David — University of Minnesota
- Study coordinator: Masopust, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.