Creating a new model to study Frontotemporal Dementia caused by MAPT mutations
iPSC-based Model to Study Frontotemporal Dementia Due to MAPT Mutation
This study is creating a special 3D model of brain cells to help us understand how a specific gene mutation related to Frontotemporal Dementia affects the brain, which could lead to new ways to treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Regenerative Research Foundation NIH-funded |
| Lab location | 1 site (Albany, UNITED STATES) |
| Project ID | NIH-11121463 on NIH RePORTER |
What this research studies
This research aims to develop a complex 3D cellular model to better understand Frontotemporal Dementia (FTD) resulting from mutations in the MAPT gene. By generating organoids that replicate the brain's structure, including the cerebral cortex, striatum, and midbrain, the study will investigate how abnormal tau protein accumulation affects brain cells and leads to cognitive and behavioral symptoms. This model will allow researchers to observe the interactions between different brain regions and how they contribute to the disease's progression, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Frontotemporal Dementia linked to MAPT gene mutations.
Not a fit: Patients with Frontotemporal Dementia not associated with MAPT mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Frontotemporal Dementia.
How similar studies have performed: Previous research has shown promise in using 3D cellular models to study tauopathies, indicating that this approach could yield valuable insights.
Where this research is happening
Albany, UNITED STATES
- Regenerative Research Foundation — Albany, United States (Active)
Researchers
- Principal investigator: Temple, Sally — Regenerative Research Foundation
- Study coordinator: Temple, Sally
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.