Creating a new model to study Frontotemporal Dementia caused by MAPT mutations

Who could benefit from this research

What this research studies

This research aims to develop a complex 3D cellular model to better understand Frontotemporal Dementia (FTD) resulting from mutations in the MAPT gene. By generating organoids that replicate the brain's structure, including the cerebral cortex, striatum, and midbrain, the study will investigate how abnormal tau protein accumulation affects brain cells and leads to cognitive and behavioral symptoms. This model will allow researchers to observe the interactions between different brain regions and how they contribute to the disease's progression, potentially leading to new therapeutic strategies.

Why it matters

Where this research is happening

• Regenerative Research Foundation
  Albany, United States Active

Researchers

• Principal investigator: Temple, Sally — Regenerative Research Foundation
• Study coordinator: Temple, Sally

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.