Creating a new method to synthesize a natural product called sarmentogenin.
Official title: Asymmetric de Novo Synthesis of a Cardenolide: The Total Synthesis of Sarmentogenin
Funded at Dartmouth College · NIH-10825062 · Data updated 2026-11-12
This study is working on a new way to make a natural substance called sarmentogenin, which could lead to new medicines that help people with certain health conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | July 24, 2024 |
| Project end | July 23, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AT012724-01 |
| Project ID | NIH-10825062 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in novel therapeutic options or those affected by conditions that may be treated with cardenolide-derived medications.
✕Less likely to help
Patients who are not interested in experimental therapies or those with conditions unrelated to the potential applications of cardenolides may not benefit from this research.
What this research studies
This research focuses on developing a new synthetic method for producing sarmentogenin, a natural product with potential therapeutic applications. By employing innovative chemical techniques, the project aims to overcome existing challenges in synthesizing cardenolides, which are known for their medicinal properties. The approach involves complex chemical transformations to create specific molecular structures that are difficult to access through natural sources. Patients may benefit from the eventual development of new medications derived from these synthesized compounds.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapeutic drugs derived from cardenolides, improving treatment options for various medical conditions.
How similar studies have gone: While the synthesis of natural products is a well-explored area, the specific approach to synthesizing cardenolides like sarmentogenin is innovative and has not been extensively tested.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Bucknam, Andrea Rachel — Dartmouth College
- Study coordinator: Bucknam, Andrea Rachel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.