Creating a new method to restore liver tissue and test drugs
Official title: Engineering a Novel Bio-Scaffold for Hepatic Tissue Restoration and Drug Screening
Funded at Florida Agricultural and Mechanical Univ · NIH-11074029 · Data updated 2026-11-12
This study is working on a new way to grow liver cells in the lab that could help improve treatments for liver diseases and make it easier to test new medicines, especially for people waiting for liver transplants.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Agricultural and Mechanical Univ NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | June 1, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $148,000 |
| NIH project number | 5R16GM145595-04 |
| Project ID | NIH-11074029 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from liver diseases, particularly those who may require a transplant or have limited treatment options.
✕Less likely to help
Patients with non-liver related health issues or those who are not candidates for liver transplantation may not benefit from this research.
What this research studies
This research focuses on developing a novel bio-scaffold that can help restore liver tissue and improve drug screening processes. By utilizing a 3D culture system, the project aims to expand liver cells from patients and create a model that mimics the natural functioning of the liver. This approach could lead to better treatment options for liver diseases, especially for patients awaiting transplants. The research involves innovative techniques in bioengineering to enhance the viability and functionality of liver cells.
Why it matters
Potential benefit: If successful, this research could provide new treatment options for patients with liver diseases and improve the success rates of liver transplants.
How similar studies have gone: While there have been attempts to create liver models, this specific approach using 3D bio-scaffolds for expanding autologous liver cells is relatively novel and has shown promising preliminary results.
Where this research is happening
-
Florida Agricultural and Mechanical Univ
Tallahassee, United States Active
Researchers
- Principal investigator: Ali, Jamel — Florida Agricultural and Mechanical Univ
- Study coordinator: Ali, Jamel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.