Creating a new method to reduce proteins in Chlamydia bacteria
Official title: Development of a novel protein depletion method in Chlamydia
Funded at University of California-Irvine · NIH-10782546 · Data updated 2026-11-12
This study is exploring a new way to target and reduce certain proteins in the Chlamydia bacteria, which causes a common sexually transmitted infection, to help researchers learn more about how these proteins work and find better treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | February 8, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $196,250 |
| NIH project number | 5R21AI171927-02 |
| Project ID | NIH-10782546 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Chlamydia trachomatis infections.
✕Less likely to help
Patients with other types of infections or those not infected with Chlamydia may not benefit from this research.
What this research studies
This research focuses on developing a novel method to deplete specific proteins in Chlamydia trachomatis, the bacterium responsible for the most common sexually transmitted infection in the U.S. By utilizing small RNAs to downregulate protein expression, the researchers aim to better understand the functions of essential genes in Chlamydia. The study will compare this new approach with existing methods like CRISPRi to determine its effectiveness in controlling protein levels. This could lead to innovative tools for studying Chlamydia and potentially developing new treatments.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for Chlamydia infections.
How similar studies have gone: Other research has shown success with similar genetic approaches, indicating potential for this novel method.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Tan, Ming — University of California-Irvine
- Study coordinator: Tan, Ming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.