Creating a new method to produce therapeutic exosomes for drug delivery
Official title: A Scalable Continuous Production Platform for Large-Scale Manufacturing of Therapeutic Exosomes
Funded at University of Notre Dame · NIH-10739425 · Data updated 2026-11-12
This study is working on a new way to make tiny delivery vehicles called exosomes that can help carry medicine directly to the right cells in your body, making treatments more effective and reliable for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project start | September 7, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $402,404 |
| NIH project number | 1R21CA277663-01A1 |
| Project ID | NIH-10739425 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who require advanced drug delivery methods for their treatments, particularly those with conditions that could benefit from targeted therapies.
✕Less likely to help
Patients who do not require drug delivery systems or those with conditions that are not addressed by exosome-based therapies may not benefit from this research.
What this research studies
This research focuses on developing a new platform for the large-scale production of therapeutic exosomes, which are tiny vesicles that can deliver drugs to specific cells in the body. The approach involves using a three-dimensional scaffold to enhance exosome production, a special material to improve drug loading efficiency, and a filtration system to isolate the exosomes with high purity and yield. By addressing current limitations in exosome production, this project aims to create a reliable method for producing these promising drug delivery vehicles for clinical use.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted drug delivery systems, improving treatment outcomes for patients.
How similar studies have gone: Other research has shown promise in using exosomes for drug delivery, but this specific approach to scalable production is relatively novel.
Where this research is happening
-
University of Notre Dame
Notre Dame, United States Active
Researchers
- Principal investigator: Wang, Yichun — University of Notre Dame
- Study coordinator: Wang, Yichun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.