Creating a new method to monitor CAR-T cell interactions in the body
Official title: Development of a novel platform for label-free monitoring of CAR-T cell interactions in vivo
Funded at Tufts University Medford · NIH-10755335 · Data updated 2026-11-12
This study is working on a new, easy-to-use device that can watch how CAR-T cells and B cells interact inside the body, which could help doctors better understand and improve CAR-T therapy for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Medford NIH-funded |
| Lab location | 1 site (Boston, UNITED STATES) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $177,279 |
| NIH project number | 5R21CA271679-02 |
| Project ID | NIH-10755335 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with B cell malignancies who are undergoing CAR-T cell therapy.
✕Less likely to help
Patients with non-B cell malignancies or those not receiving CAR-T cell therapy may not benefit from this research.
What this research studies
This research focuses on developing a novel, non-invasive device to monitor the interactions between CAR-T cells and B cells in real-time within the body. By utilizing advanced flow cytometry techniques, the researchers aim to detect unique optical signatures that indicate how these cells interact, which is crucial for improving CAR-T cell therapy outcomes. The goal is to provide a tool that can help predict treatment responses and manage potential toxicities associated with CAR-T therapy. This innovative approach could lead to better monitoring and optimization of CAR-T cell therapies for patients.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring of CAR-T cell therapies, enhancing treatment effectiveness and reducing adverse effects for patients.
How similar studies have gone: Previous studies have shown promise in using flow cytometry techniques for monitoring cell interactions, suggesting that this approach could be effective.
Where this research is happening
-
Tufts University Medford
Boston, United States Active
Researchers
- Principal investigator: Georgakoudi, Irene — Tufts University Medford
- Study coordinator: Georgakoudi, Irene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.