Creating a new method to label immune cell structures involved in fighting infections and cancer
Development of a technique for specific labelling phagosome-derived membranous structures in dendritic cells
['FUNDING_R03'] · FLORIDA STATE UNIVERSITY · NIH-10665759
This study is looking at special immune cells called dendritic cells to see how they help the body fight infections and cancer, using tiny particles that light up when the cells take them in, which could help us understand and improve our immune responses.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FLORIDA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (TALLAHASSEE, UNITED STATES) |
| Trial ID | NIH-10665759 on ClinicalTrials.gov |
What this research studies
This research focuses on dendritic cells, which are crucial immune cells that help the body recognize and respond to pathogens and cancer cells. The project aims to develop a novel technique that uses engineered microparticles to label and track membranous structures formed in these cells during the process of cross-presentation, where they present antigens to other immune cells. By using a special dye that is released only after the microparticles are ingested by the dendritic cells, researchers hope to gain a clearer understanding of how these immune processes work. This could lead to better insights into how the immune system can be harnessed to fight infections and malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infectious diseases or cancers who may benefit from advancements in immunotherapy.
Not a fit: Patients with non-infectious, non-malignant conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses, potentially leading to improved treatments for infections and cancers.
How similar studies have performed: While the specific technique being developed is novel, similar approaches in immune cell labeling have shown promise in other studies.
Where this research is happening
TALLAHASSEE, UNITED STATES
- FLORIDA STATE UNIVERSITY — TALLAHASSEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUAN, JINGJIAO — FLORIDA STATE UNIVERSITY
- Study coordinator: GUAN, JINGJIAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, Communicable Diseases