Creating a new method to evaluate diagnostic tests in medicine
Official title: Development of a new weighted ROC (WROC) analysis - Resubmission - 1
Funded at University of Chicago · NIH-11014366 · Data updated 2026-11-12
This study is working on a new way to make medical imaging tests more accurate, which could help doctors make better decisions for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $361,166 |
| NIH project number | 5R01EB034517-02 |
| Project ID | NIH-11014366 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals undergoing diagnostic imaging or testing for various medical conditions, particularly cancers.
✕Less likely to help
Patients who are not undergoing diagnostic imaging or testing may not receive any benefit from this research.
What this research studies
This research aims to develop a new weighted receiver operating characteristic (WROC) analysis to improve the evaluation of diagnostic performance in medical imaging and other areas. By introducing a case weighting factor, the WROC analysis seeks to reduce bias from non-random case samples, leading to more accurate clinical performance assessments. The project will involve creating algorithms and software that will be shared with the medical community, allowing for broader application and validation of this innovative approach. Patients may benefit from improved diagnostic accuracy and better-informed clinical decisions as a result of this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnostic evaluations, ultimately improving patient care and outcomes.
How similar studies have gone: Other research has shown success with similar approaches in improving diagnostic evaluation methods, making this a promising area of investigation.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Jiang, Yulei — University of Chicago
- Study coordinator: Jiang, Yulei
Related research
Other NIH-funded projects on the same topics.
-
Education and violence: Can high-dosage tutoring reduce youth violence
A large study in Chicago schools will test whether high-dosage tutoring for students can lessen youth violence by improving learning and outcomes.
-
Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
-
Lens proteins, cell stress, and cataracts in kids and adults
A study aims to understand how lens proteins and cellular stress contribute to cataracts, in both humans and mice, with the goal of guiding prevention or treatment.
-
Understanding how neurons keep their identity and function for life
Scientists are studying how nerve cells maintain their distinctive identity and function from development through aging, using human-derived neurons and a simple worm model to uncover the long-term control of brain cell behavior.
-
Cardiac Sarcomere Protein Quality Control in Health and Disease
A heart-focused study looking at how heart muscle proteins get misfolded and how the cell’s cleanup system might fix this to protect heart function.
-
Communication Bridge: Improving language therapy for people with primary progressive aphasia
A proven language-therapy program called Communication Bridge helps people with primary progressive aphasia improve and maintain how they communicate with others.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.