Creating a new method to analyze genetic changes in Crohn's disease
Official title: Development of a high-throughput epigenomic mapping platform to molecularly phenotype Crohn's disease
Funded at Epicypher, INC. · NIH-10683287 · Data updated 2026-11-12
This study is looking at how changes in genes affect people with Crohn's disease, so we can find better ways to predict how the disease will progress and how well different treatments might work for each person, ultimately helping to create more personalized care for patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Epicypher, INC. NIH-funded |
| Lab location | 1 site (Research Triangle Park, UNITED STATES) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,002,068 |
| NIH project number | 5R44DK131770-03 |
| Project ID | NIH-10683287 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Crohn's disease who are seeking more effective treatment options.
✕Less likely to help
Patients with other gastrointestinal disorders that are not Crohn's disease may not receive any benefit from this research.
What this research studies
This research focuses on developing a high-throughput platform to map epigenomic changes in patients with Crohn's disease, a chronic gastrointestinal condition. By analyzing how gene expression is regulated in different subtypes of Crohn's, the research aims to identify unique biomarkers that can predict disease progression and treatment responses. The approach involves innovative genomic mapping techniques that are more efficient and cost-effective than current methods, making it suitable for clinical applications. Patients may benefit from more personalized treatment options based on their specific disease characteristics.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with Crohn's disease.
How similar studies have gone: Previous research has shown promise in using genomic mapping techniques to identify biomarkers in other diseases, suggesting potential success for this novel approach.
Where this research is happening
-
Epicypher, INC.
Research Triangle Park, United States Active
Researchers
- Principal investigator: Johnstone, Andrea Lynn — Epicypher, INC.
- Study coordinator: Johnstone, Andrea Lynn
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.