Creating a new measure to assess early signs of psychosis in young people

DDT-COA-000-163 Accelerating the FDA COA Qualification Plan for the PSYCHS as a ClinRO measure

NIH-funded research Yale University · NIH-10836892

This study is working on a new tool called PSYCHS to help measure early signs of psychosis in young people, so that doctors can better understand how well treatments are working for those at risk.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionYale University NIH-funded
Lab location1 site (New Haven, United States)
Project IDNIH-10836892 on NIH RePORTER

What this research studies

This research focuses on developing a new clinical outcome assessment tool called the PSYCHS, which measures the severity of early symptoms of psychosis in youth and young adults. The goal is to create a qualification plan that will allow this tool to be recognized by the FDA, facilitating its use in future clinical trials aimed at finding effective treatments for individuals at high risk for psychosis. By harmonizing existing assessment instruments, the PSYCHS aims to provide a reliable way to evaluate treatment efficacy in this vulnerable population.

Who could benefit from this research

Good fit: Ideal candidates for this research are youth and young adults who exhibit early symptoms of psychosis, such as delusions or hallucinations.

Not a fit: Patients who do not exhibit any symptoms of psychosis or are not at risk for developing psychosis may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to the development of effective treatments for young individuals experiencing early signs of psychosis.

How similar studies have performed: Other research has shown success in developing clinical outcome measures for psychiatric conditions, indicating that this approach has potential.

Where this research is happening

New Haven, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.