Creating a new imaging method to detect inflammation in neurodegenerative diseases
Developing a PET tracer targeting myeloperoxidase activity for neurodegenerative diseases
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10519568
This study is exploring a new way to use imaging to spot early signs of brain inflammation linked to Alzheimer's and Parkinson's, which could help track how well treatments are working for people with these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10519568 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a non-invasive imaging technique that targets myeloperoxidase (MPO) activity, which is linked to neuroinflammation in diseases like Alzheimer's and Parkinson's. By identifying and measuring MPO levels, the research aims to detect early signs of neurodegenerative diseases before significant damage occurs. This approach could also help monitor how well current and new treatments are working. The study involves transcriptome profiling to understand the role of MPO in inflammation and its potential as a treatment target.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals in the early stages of Alzheimer's disease, Parkinson's disease, or other related neurodegenerative conditions.
Not a fit: Patients with advanced neurodegenerative diseases or those without any neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better monitoring of neurodegenerative diseases, improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promise in targeting neuroinflammation for neurodegenerative diseases, indicating that this approach could be effective.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, JOHN W — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: CHEN, JOHN W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia, Alzheimers disease