Creating a new human intestinal model for testing drugs
Official title: A Novel Multi-Lineage Human Intestinal Organoid Screening Platform for Drug Discovery and Preclinical Testing
Funded at Intero Biosystems INC. · NIH-11183379 · Data updated 2026-11-12
This study is working on creating a mini version of the human intestine using stem cells, which will help researchers test new medicines more accurately and understand conditions like intestinal fibrosis better, ultimately making drug development safer and more effective for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Intero Biosystems INC. NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 20, 2025 |
| Project end | June 19, 2026 |
| Funding year | 2025 |
| Award (this year) | $349,952 |
| NIH project number | 1R41TR005379-01A1 |
| Project ID | NIH-11183379 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that affect the intestine, particularly those related to fibrosis or other gastrointestinal disorders.
✕Less likely to help
Patients with conditions unrelated to intestinal health or those who do not have a need for new drug therapies may not benefit from this research.
What this research studies
This research focuses on developing a novel human intestinal organoid system that closely mimics the structure and function of the human intestine. By using stem cells, the team aims to create a model that includes various tissue types found in the intestine, allowing for more accurate testing of drug candidates. The project will validate this model for assessing cell viability and toxicity, and will also create a model for studying intestinal fibrosis, which is important for evaluating drug efficacy. This approach seeks to improve the drug development process by providing a more reliable platform for preclinical testing.
Why it matters
Potential benefit: If successful, this research could lead to more effective drug development, reducing the failure rate of new drugs and ultimately improving treatment options for patients.
How similar studies have gone: Other research has shown promise in using organoid models for drug testing, indicating that this approach could be a significant advancement in the field.
Where this research is happening
-
Intero Biosystems INC.
Ann Arbor, United States Active
Researchers
- Principal investigator: Childs, Charlie — Intero Biosystems INC.
- Study coordinator: Childs, Charlie
Related research
Other NIH-funded projects on the same topics.
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A human gut organoid model with gut-like movement for drug testing
A new human gut organoid platform that moves like real intestines is being developed to help discover and test drugs for GI motility disorders.
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Human intestinal organoid screening platform for drug discovery
A patient-friendly project that aims to create advanced human intestinal models to better predict how drugs will behave in people.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.