Creating a new EEG tool to measure brain changes in Alzheimer's disease
Official title: Developing a novel EEG-based index for evaluating amyloid and tau burden in Alzheimer's Disease
Funded at Spark Neuro INC. · NIH-10769847 · Data updated 2026-11-12
This study is working on a new way to use brain wave recordings to help detect harmful proteins in the brains of people with Alzheimer's disease, which could lead to earlier and more accurate diagnoses, making it easier for patients and doctors to understand cognitive health.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Spark Neuro INC. NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,175,044 |
| NIH project number | 5R44AG080940-02 |
| Project ID | NIH-10769847 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on developing a novel index using electroencephalography (EEG) to evaluate the presence of amyloid and tau proteins in the brains of individuals with Alzheimer's disease. By combining EEG technology with machine learning, the project aims to create a continuous score that reflects the pathological burden of Alzheimer's, potentially allowing for earlier and more accurate diagnosis. The research will utilize cerebrospinal fluid (CSF) data collected from patients to enhance the software platform, making it more user-friendly and effective for assessing cognitive health.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of Alzheimer's disease, improving patient management and treatment outcomes.
How similar studies have gone: Previous research has shown promise in using EEG-based biomarkers for early detection of neurodegenerative diseases, indicating that this approach may be effective.
Where this research is happening
-
Spark Neuro INC.
New York, United States Active
Researchers
- Principal investigator: Yoder, Keith — Spark Neuro INC.
- Study coordinator: Yoder, Keith
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.