Creating a new diagnostic tool for quick and accurate biomarker detection.
Official title: Development of a Novel Split Enzyme Diagnostic Platform for Use at the Point of Care
Funded at Clemson University · NIH-11182852 · Data updated 2026-11-12
This study is working on a new, easy-to-use test that can quickly and affordably detect important health markers right where you receive care, helping doctors make better decisions without needing costly lab tests.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00EB034778-02 |
| Project ID | NIH-11182852 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals requiring rapid diagnostic testing for various medical conditions that involve biomarker detection.
✕Less likely to help
Patients with conditions that do not involve detectable biomarkers or those who are not in need of point-of-care testing may not benefit from this research.
What this research studies
This research focuses on developing a novel diagnostic platform that allows for rapid and cost-effective detection of biomarkers directly at the point of care. By utilizing innovative protein-based signaling networks, the project aims to enhance the sensitivity of detecting low concentrations of proteins and small molecules, which are crucial for accurate clinical decision-making. The approach involves combining split enzyme reconstitution, autocatalytic feedback loops, and small molecule biosensors to create a system that can amplify signals for better detection. This could potentially reduce reliance on expensive lab tests and improve the accuracy of diagnoses.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnoses for patients, improving treatment outcomes.
How similar studies have gone: Previous research has shown promise in using protein-based signaling for diagnostics, indicating that this approach could be a significant advancement in the field.
Where this research is happening
-
Clemson University
Clemson, United States Active
Researchers
- Principal investigator: Majors, Catherine E. — Clemson University
- Study coordinator: Majors, Catherine E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.