Creating a new adjuvant to enhance influenza vaccines
Official title: DEVELOPMENT OF SMALL-MOLECULE DUAL ADJUVANT SYSTEM FOR INFLUENZA VIRUS VACCINE
Funded at Scripps Institution of Oceanography · NIH-10935796 · Data updated 2026-11-12
This study is testing a new ingredient called Fos47 that could help make flu vaccines work better and last longer, especially for older adults and people with ongoing health issues, before it’s tried in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Institution of Oceanography NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | September 30, 2023 |
| Project end | September 29, 2028 |
| Funding year | 2023 |
| Award (this year) | $2,471,790 |
| NIH project number | 75N93023C00043-0-9999-1 |
| Project ID | NIH-10935796 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include elderly individuals and patients with chronic diseases who are at higher risk for influenza complications.
✕Less likely to help
Patients who are not at risk for influenza or those who have already received effective vaccinations may not benefit from this research.
What this research studies
This research focuses on developing a new immune-boosting adjuvant called Fos47 to improve the effectiveness and longevity of influenza vaccines. Current vaccines often provide limited protection, especially for the elderly and those with chronic diseases, necessitating annual updates to combat new virus strains. The study will evaluate Fos47's protective efficacy in animal models and determine the best dosage, administration route, and frequency for immunization before moving to human clinical trials. This approach aims to enhance the immune response against various influenza strains.
Why it matters
Potential benefit: If successful, this research could lead to more effective and longer-lasting influenza vaccines, particularly benefiting vulnerable populations.
How similar studies have gone: Previous research has shown promise in developing adjuvants to enhance vaccine efficacy, indicating potential success for this novel approach.
Where this research is happening
-
Scripps Institution of Oceanography
La Jolla, United States Active
Researchers
- Principal investigator: Lapek, Jennifer — Scripps Institution of Oceanography
- Study coordinator: Lapek, Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.