Creating a mouse model to understand and treat lung cancer-related weight loss
Development of a clinically relevant mouse model of lung cancer cachexia to study pathoetiology and therapeutic strategies
This study is creating a special type of mouse to help us understand the weight loss and muscle loss that lung cancer patients experience, so we can find better ways to help those who are struggling with these symptoms.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10899609 on NIH RePORTER |
What this research studies
This research focuses on developing a mouse model that mimics the weight loss and muscle wasting seen in lung cancer patients, known as cancer cachexia. By studying how lung tumors interact with the body to cause these symptoms, researchers aim to uncover the underlying mechanisms and potential therapeutic strategies. The project will utilize genetically modified mice with specific mutations to better replicate the human condition, allowing for more relevant findings that could lead to improved treatments for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with lung cancer, particularly those experiencing significant weight loss or muscle wasting.
Not a fit: Patients with early-stage lung cancer who do not exhibit symptoms of cachexia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively combat cancer cachexia, improving the quality of life and treatment outcomes for lung cancer patients.
How similar studies have performed: Previous studies have shown promise in using animal models to understand cancer cachexia, but this specific approach aims to fill gaps in existing research by creating a more clinically relevant model.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Toth, Michael J — University of Vermont & St Agric College
- Study coordinator: Toth, Michael J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.