Creating a mouse model to test new treatments for a rare aggressive cancer.
Developing humanized Nut Carcinoma mouse model for developing NUTM1 targeted therapies.
This study is creating special mice that have a type of cancer called NUT carcinoma, which is tough to treat, to help researchers learn more about how this cancer grows and to find better treatments for people with it.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11005006 on NIH RePORTER |
What this research studies
This research focuses on developing a humanized mouse model for NUT carcinoma, a rare and aggressive cancer with a poor prognosis. The study aims to investigate the role of the BRD4-NUTM1 fusion gene, which is crucial for the cancer's growth, and to explore targeted therapies that can effectively inhibit this gene. By using genetically engineered mice that mimic human NUT carcinoma, researchers hope to better understand the disease and test new treatment options. This approach could lead to more effective therapies for patients suffering from this challenging condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old diagnosed with NUT carcinoma or those with a strong genetic predisposition to this type of cancer.
Not a fit: Patients with other types of cancer or those over the age of 11 may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that significantly improve survival rates for patients with NUT carcinoma.
How similar studies have performed: While research on targeted therapies for NUT carcinoma is limited, the development of similar mouse models has shown promise in other cancer types, indicating potential for success in this novel approach.
Where this research is happening
East Lansing, United States
- Henry Ford Health + Michigan State University Health Sciences — East Lansing, United States (Active)
Researchers
- Principal investigator: Gu, Bin — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Gu, Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.