Creating a mouse model to study human-like telomere aging
A mouse model with humanized telomere homeostasis
['FUNDING_R01'] · WASHINGTON STATE UNIVERSITY · NIH-10909044
This study is creating special mice that act like humans to help scientists learn more about how our cells age and how that relates to diseases like cancer, which could lead to better health insights for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON STATE UNIVERSITY (nih funded) |
| Locations | 1 site (PULLMAN, UNITED STATES) |
| Trial ID | NIH-10909044 on ClinicalTrials.gov |
What this research studies
This research aims to develop a mouse model that mimics human telomere homeostasis, which is crucial for understanding human aging and cancer. By engineering a specific gene from humans into mice, the researchers hope to replicate the way human cells age and how telomeres shorten over time. This model will allow scientists to explore the mechanisms of aging and the development of age-related diseases in a controlled environment. Patients may benefit from insights gained about telomere dynamics and their implications for health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals interested in the biological mechanisms of aging and cancer.
Not a fit: Patients with conditions unrelated to aging or cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases and cancers.
How similar studies have performed: Other research has shown success in using engineered mouse models to study human diseases, making this approach promising.
Where this research is happening
PULLMAN, UNITED STATES
- WASHINGTON STATE UNIVERSITY — PULLMAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHU, JIYUE — WASHINGTON STATE UNIVERSITY
- Study coordinator: ZHU, JIYUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancers