Creating a mouse model to study hepatitis B virus infection
Breaching the species barrier: Towards an immunocompetent HBV-susceptible mouse model
This study is creating a special type of mouse that can get infected with the hepatitis B virus to help scientists learn more about the virus and find better treatments for people living with chronic hepatitis B.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11114005 on NIH RePORTER |
What this research studies
This research aims to develop a new mouse model that can be infected with the hepatitis B virus (HBV), which is crucial for understanding and potentially curing chronic HBV infections. Current treatments can suppress the virus but do not eliminate it, and existing animal models are not suitable for studying the immune response to HBV. By engineering mice that can support HBV infection and have a functional immune system, researchers hope to explore new therapeutic strategies that could restore the immune response against the virus. This innovative approach could lead to breakthroughs in treatment options for patients with chronic hepatitis B.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic hepatitis B infection who are seeking new treatment options.
Not a fit: Patients with acute hepatitis B or those who do not have hepatitis B infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments or even a cure for chronic hepatitis B infection.
How similar studies have performed: While there have been attempts to create animal models for HBV, this specific approach of using immunocompetent mice is novel and has not been extensively tested.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Rice, Charles M — Rockefeller University
- Study coordinator: Rice, Charles M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.