Creating a mouse model to study early Alzheimer's disease pathology
Official title: A Mouse Model for Braak I/II Alzheimer's Pathology
Funded at University of Wisconsin-Madison · NIH-11184213 · Data updated 2026-11-12
This study is creating a new mouse model to help us understand the early changes in the brain that happen with Alzheimer's disease, so we can learn more about how different factors work together and find new ways to help people with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $187,715 |
| NIH project number | 5R21AG085588-02 |
| Project ID | NIH-11184213 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals at risk for Alzheimer's disease or those in the early stages of cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
What this research studies
This research aims to develop a new mouse model that mimics early-stage Alzheimer's disease pathology, specifically Braak stage I/II. By studying this model, researchers will investigate the interactions between amyloidosis, tauopathy, and neuroinflammation, which are key factors in Alzheimer's disease. The study will involve detailed examinations of the brain's cellular and molecular changes over time, providing insights into how these processes contribute to the progression of Alzheimer's. This model could help identify potential therapeutic targets for intervention.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of Alzheimer's disease mechanisms and pave the way for new treatments.
How similar studies have gone: Previous research has shown success in using animal models to study Alzheimer's disease, making this approach promising yet still innovative.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Huang, Zhen — University of Wisconsin-Madison
- Study coordinator: Huang, Zhen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.