Creating a mouse model to study a specific type of lung cancer
A Genetically Tractable Mouse Model for PRKCI-driven Lung Squamous Cell Carcinoma
This study is creating special mice to help scientists learn more about lung squamous cell carcinoma, a tough type of lung cancer, so they can find new ways to treat it and help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-10862864 on NIH RePORTER |
What this research studies
This research focuses on developing a genetically modified mouse model to better understand lung squamous cell carcinoma (LUSC), a common and aggressive form of lung cancer. By investigating the genetic alterations that drive this cancer, particularly the loss of the TP53 gene and changes on chromosome 3q26, the researchers aim to identify potential therapeutic targets. The study will utilize advanced genomic analysis and mouse genetics to explore how these alterations contribute to cancer development and progression. Patients may benefit from insights gained that could lead to new treatment strategies for LUSC.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals diagnosed with lung squamous cell carcinoma or those at high risk for developing this type of cancer.
Not a fit: Patients with other types of lung cancer, such as lung adenocarcinoma, or those without lung cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve outcomes for patients with lung squamous cell carcinoma.
How similar studies have performed: Previous research has shown success in using genetically modified mouse models to study other types of cancer, suggesting that this approach may yield valuable insights for lung squamous cell carcinoma as well.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Fields, Alan P. — Mayo Clinic Jacksonville
- Study coordinator: Fields, Alan P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.