Creating a mouse model to study a rare and aggressive cancer called NUT carcinoma
Official title: Developing a clinically-relevant genetically engineered mouse model for Nut carcinoma
Funded at Michigan State University · NIH-11001987 · Data updated 2026-11-12
This study is creating a special type of mouse to help us learn more about NUT carcinoma, a tough cancer, so we can figure out how it develops and find better treatments that target its unique features.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | January 5, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $441,475 |
| NIH project number | 5R37CA269076-03 |
| Project ID | NIH-11001987 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with NUT carcinoma or those with genetic predispositions to this type of cancer.
✕Less likely to help
Patients with other types of cancer unrelated to NUT carcinoma may not benefit from this research.
What this research studies
This research focuses on developing a genetically engineered mouse model to better understand NUT carcinoma, a highly aggressive cancer linked to specific genetic changes. The study aims to investigate how the BRD4-NUTM1 fusion protein drives this cancer and why it is lethal in most cells but can survive in certain cancer cells. By using this mouse model, researchers hope to identify the origins of NUT carcinoma and explore new treatment strategies that target the unique aspects of the NUTM1 protein, potentially leading to more effective therapies.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients suffering from NUT carcinoma, improving treatment outcomes.
How similar studies have gone: While research on NUT carcinoma is limited, the development of genetically engineered models has shown promise in understanding other aggressive cancers, suggesting potential for success in this novel approach.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Gu, Bin — Michigan State University
- Study coordinator: Gu, Bin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.