Creating a mouse model to study a rare and aggressive cancer called NUT carcinoma
Developing a clinically-relevant genetically engineered mouse model for Nut carcinoma
This study is creating a special type of mouse to help us learn more about NUT carcinoma, a tough cancer, so we can figure out how it develops and find better treatments that target its unique features.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11001987 on NIH RePORTER |
What this research studies
This research focuses on developing a genetically engineered mouse model to better understand NUT carcinoma, a highly aggressive cancer linked to specific genetic changes. The study aims to investigate how the BRD4-NUTM1 fusion protein drives this cancer and why it is lethal in most cells but can survive in certain cancer cells. By using this mouse model, researchers hope to identify the origins of NUT carcinoma and explore new treatment strategies that target the unique aspects of the NUTM1 protein, potentially leading to more effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with NUT carcinoma or those with genetic predispositions to this type of cancer.
Not a fit: Patients with other types of cancer unrelated to NUT carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients suffering from NUT carcinoma, improving treatment outcomes.
How similar studies have performed: While research on NUT carcinoma is limited, the development of genetically engineered models has shown promise in understanding other aggressive cancers, suggesting potential for success in this novel approach.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Gu, Bin — Michigan State University
- Study coordinator: Gu, Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.