Creating a mouse model for treating aggressive brain tumors with a virus
Development of murine glioblastoma model for oncolytic HSV therapy
['FUNDING_OTHER'] · AUGUSTA UNIVERSITY · NIH-10793356
This study is creating a special mouse model to help researchers find better ways to treat aggressive brain tumors using a virus that can target and kill cancer cells, aiming to improve options for patients facing tough challenges with their condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-10793356 on ClinicalTrials.gov |
What this research studies
This research aims to develop a mouse model that mimics grade IV brain tumors, which are known for their poor prognosis. The model will be designed to be sensitive to HSV-1 infection, allowing researchers to test the safety and effectiveness of oncolytic HSV-1 (oHSV) therapies. By using this model, scientists hope to better understand how these viral therapies can be utilized to treat aggressive brain tumors, which currently have limited treatment options. The project addresses the urgent need for alternative therapies in the face of dismal survival rates for patients with these tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with grade IV brain tumors who have limited treatment options.
Not a fit: Patients with non-brain tumors or those who do not have grade IV brain tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with grade IV brain tumors.
How similar studies have performed: Other research has shown promise with similar oncolytic virus therapies in treating various cancers, indicating a potential for success in this novel approach.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAUR, BALVEEN — AUGUSTA UNIVERSITY
- Study coordinator: KAUR, BALVEEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.