Creating a model to understand how blood flow in the brain responds to neural activity
Official title: A microphysiological model of the neurovascular unit capable of demonstrating neurovascular coupling
Funded at Vanderbilt University · NIH-11063534 · Data updated 2026-11-12
This study is exploring how different brain cells work together to control blood flow, which is important for keeping our thinking sharp, and it could help find new treatments for memory problems related to conditions like Alzheimer's.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | March 15, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $226,877 |
| NIH project number | 1R21MH136576-01A1 |
| Project ID | NIH-11063534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing cognitive decline or at risk for Alzheimer's disease and related dementias.
✕Less likely to help
Patients with cognitive impairments not related to neurovascular dysfunction may not benefit from this research.
What this research studies
This research focuses on developing a new model of the neurovascular unit, which is essential for understanding how blood flow in the brain adjusts to meet its changing energy needs. By simulating the interactions between different cell types in the brain, the researchers aim to demonstrate neurovascular coupling, a process that is crucial for maintaining cognitive function. The study will utilize advanced 3D cell culture techniques to replicate the brain's environment and investigate the mechanisms behind blood flow regulation. This could lead to insights into therapies for cognitive decline associated with diseases like Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to improve cognitive function in patients with neurodegenerative diseases.
How similar studies have gone: Previous research has shown promise in using microphysiological models to study brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Bellan, Leon Marcel — Vanderbilt University
- Study coordinator: Bellan, Leon Marcel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.