Creating a model to test new treatments for drug-resistant hookworms
Official title: Development of a rodent model for anthelmintic testing against multidrug resistant hookworms
Funded at George Washington University · NIH-10927198 · Data updated 2026-11-12
This study is looking to create a rodent model to test new medicines that can fight stubborn hookworms, which are parasites that can make both people and pets very sick, especially in those who are most at risk.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 11, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $201,875 |
| NIH project number | 5R21AI173403-02 |
| Project ID | NIH-10927198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals, especially children and pets, who are at risk of hookworm infections or are already infected with drug-resistant strains.
✕Less likely to help
Patients who are not affected by hookworm infections or those who do not have access to the necessary treatment options may not benefit from this research.
What this research studies
This research focuses on developing a rodent model to test new anthelmintic drugs against multidrug-resistant hookworms, which are parasites that can cause severe health issues in both humans and animals. The study aims to understand how these resistant strains develop and spread, particularly in vulnerable populations and pets. By using a rodent model, researchers can simulate the effects of these parasites and evaluate the effectiveness of potential new treatments. This approach is crucial for finding solutions to combat the growing problem of drug resistance in hookworms.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective new treatments for hookworm infections, improving health outcomes for affected individuals.
How similar studies have gone: While there has been significant research on hookworms, the specific approach of developing a rodent model for testing against multidrug-resistant strains is relatively novel.
Where this research is happening
-
George Washington University
Washington, United States Active
Researchers
- Principal investigator: Hawdon, John M — George Washington University
- Study coordinator: Hawdon, John M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.