Creating a model to study how the lungs and bone marrow interact during influenza infections
A Microphysiological Mimicry of Human Lung-Bone Marrow Organ-Organ Crosstalk On-a-Chip
This study is creating a special lab model that mimics how the lungs and bone marrow work together during flu infections, helping researchers learn how different flu strains affect our health, which could lead to better ways to prevent and treat the flu for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10695907 on NIH RePORTER |
What this research studies
This research aims to develop an advanced in vitro model that mimics the interaction between human lungs and bone marrow during influenza A virus infections. By using Organ-on-Chip technology, the project will simulate how different immune cells produced in the bone marrow respond to respiratory infections. This model will help researchers understand the pathogenicity of various influenza strains and how they affect human health. Patients may benefit from insights gained through this research, which could lead to better prevention and treatment strategies for influenza infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are interested in contributing to advancements in understanding respiratory infections.
Not a fit: Patients with non-respiratory conditions or those who are not adults may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and managing influenza outbreaks, ultimately enhancing patient care.
How similar studies have performed: Other research has shown promise in using Organ-on-Chip technology for studying infectious diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Hajipouran Benam, Kambez — University of Pittsburgh at Pittsburgh
- Study coordinator: Hajipouran Benam, Kambez
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.