Creating a microfluidic model to study organ preservation injury in blood vessels
Official title: Development of Capillary-on-Chip for the Study of Preservation Injury on Microvascular Endothelial Cells
Funded at Massachusetts General Hospital · NIH-10996895 · Data updated 2026-11-12
This study is looking at how injuries from preserving organs can harm tiny blood vessel cells, which are really important for successful transplants, and it aims to find ways to protect these cells so that organs can last longer and be available for more people in need of a transplant.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2027 |
| Funding year | 2024 |
| Award (this year) | $76,984 |
| NIH project number | 1F32HL176334-01 |
| Project ID | NIH-10996895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals awaiting organ transplants, particularly those in need of vascular composite allografts.
✕Less likely to help
Patients who are not candidates for organ transplantation or those with conditions unrelated to organ preservation may not benefit from this research.
What this research studies
This research investigates how preservation injuries affect microvascular endothelial cells, which are crucial for successful organ transplantation. By developing a microfluidic model that mimics the microvasculature, the research aims to understand the damage caused during the preservation of organs. This approach will allow researchers to explore potential therapeutic strategies to protect these cells and improve organ viability. The ultimate goal is to extend the preservation time of organs, making them more accessible for transplantation.
Why it matters
Potential benefit: If successful, this research could significantly increase the availability of organs for transplantation by improving preservation techniques.
How similar studies have gone: Previous research has shown promise in similar approaches to studying organ preservation, indicating potential for success in this novel application.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Ellis, Bradley Wayne — Massachusetts General Hospital
- Study coordinator: Ellis, Bradley Wayne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.