Creating a low-cost test to detect early ovarian cancer in high-risk women using Pap tests
Development of a low-cost epigenetic screening assay for Pap specimen-based detection of early-stage ovarian cancer in high-risk women
This study is working on a new, affordable test that can help find early signs of ovarian cancer in women who are at higher risk, especially those with family histories or certain genetic mutations, by looking at samples from routine Pap tests to spot early changes that might lead to cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11082985 on NIH RePORTER |
What this research studies
This research focuses on developing a cost-effective epigenetic screening assay that can detect early-stage ovarian cancer in women at high risk, particularly those with familial histories or BRCA mutations. The approach involves analyzing Pap specimens to identify specific biomarkers associated with early cancer development. By targeting the detection of precursor lesions that typically go unnoticed until advanced stages, the research aims to improve early diagnosis and treatment options for these patients. The methodology includes enhancing the sensitivity and specificity of current biomarkers to ensure reliable results.
Who could benefit from this research
Good fit: Ideal candidates for this research are women with a familial history of ovarian cancer or those who carry BRCA mutations.
Not a fit: Patients without a familial risk or BRCA mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of ovarian cancer, significantly improving survival rates for high-risk women.
How similar studies have performed: Previous studies have shown promise in using Pap tests for cancer detection, indicating that this approach could be a viable method for early diagnosis.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wang, Tza-Huei Jeff — Johns Hopkins University
- Study coordinator: Wang, Tza-Huei Jeff
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.