Creating a long-lasting bioprosthetic ovary transplant
Defining the microenvironment that will enable a long-term bioprosthetic ovary transplant
This study is working on creating a special type of ovary that can be transplanted to help cancer survivors who have lost their fertility and hormone production because of their treatments, using cool technology like 3D printing to make it work well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11083573 on NIH RePORTER |
What this research studies
This research focuses on developing a bioprosthetic ovary that can be transplanted to restore fertility and hormone production in cancer survivors who have experienced premature ovarian insufficiency due to cancer treatments. The approach involves understanding and recreating the microenvironment necessary for the proper function of ovarian tissue. By utilizing advanced bioengineering techniques, including 3D printing, the research aims to create a viable solution that can support the activation and maintenance of ovarian follicles over an extended period.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric cancer survivors who have undergone treatments leading to premature ovarian insufficiency and are seeking options for fertility preservation.
Not a fit: Patients who have not experienced ovarian damage from cancer treatments or those who are not interested in fertility restoration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide cancer survivors with a new option for restoring fertility and hormone function, significantly improving their quality of life.
How similar studies have performed: While the concept of bioprosthetic organs is being explored, this specific approach to creating a bioprosthetic ovary is novel and has not been extensively tested in previous research.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Laronda, Monica M — Lurie Children's Hospital of Chicago
- Study coordinator: Laronda, Monica M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.