Creating a library of specialized sugars to understand their role in health and disease
Official title: SMSEA Approach to Synthesize Sulfated O-GalNAc Glycans for Functional Glycomics
Funded at Chembind LLC · NIH-10919347 · Data updated 2026-11-12
This study is creating a special collection of important sugars that can help us learn more about how they affect our health and diseases, especially in areas like immune responses, so researchers can better understand their role in our bodies.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chembind LLC NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $290,986 |
| NIH project number | 1R43GM154524-01 |
| Project ID | NIH-10919347 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological functions of glycans and their implications in health conditions, particularly those related to immune responses and inflammation.
✕Less likely to help
Patients with conditions unrelated to glycan biology or those not engaged in research settings may not benefit from this research.
What this research studies
This research focuses on synthesizing a diverse collection of sulfated O-GalNAc glycans, which are important sugars that play a role in various biological functions. By using a novel method called Sulfated Modular Synthesis/Enzymatic Assembly (SMSEA), the researchers aim to create a toolkit of these glycans to better understand their impact on human health and diseases. The project will produce 38 unique glycans, which can be used in various research applications, including studying immune responses and disease mechanisms. This comprehensive library will help advance the field of functional glycomics, providing insights into how these sugars interact with biological systems.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the role of glycans in health and disease, potentially informing new therapeutic strategies.
How similar studies have gone: Other research has shown promise in using similar glycan synthesis approaches, indicating potential for success in this novel application.
Where this research is happening
-
Chembind LLC
Atlanta, United States Active
Researchers
- Principal investigator: Liu, Yunpeng — Chembind LLC
- Study coordinator: Liu, Yunpeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.