Creating a library of heparan sulfate mimetics for Alzheimer's disease
Official title: Synthesis of the library of heparan sulfate hexasaccharide mimetics
Funded at Glycan Therapeutics Corporation · NIH-10932794 · Data updated 2026-11-12
This study is working on creating new compounds that mimic a specific sugar found in the body, which could help us learn more about Alzheimer's disease and other health issues, with the hope of finding better ways to understand and treat these conditions.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Glycan Therapeutics Corporation NIH-funded |
| Lab location | 1 site (Raleigh, UNITED STATES) |
| Project start | September 21, 2023 |
| Project end | September 14, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,075,154 |
| NIH project number | 4R44GM145004-02 |
| Project ID | NIH-10932794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not receive benefits from this research.
What this research studies
This research focuses on developing a library of heparan sulfate hexasaccharide mimetics, which are important for understanding biological processes related to Alzheimer's disease and other conditions. The project aims to synthesize these mimetics using innovative methods that simplify the complex process of creating diverse heparan sulfate structures. By collaborating with industry, the researchers will create a variety of compounds that can be used to study their interactions with biological partners, potentially leading to new insights into disease mechanisms and treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for Alzheimer's disease and improve our understanding of its biological mechanisms.
How similar studies have gone: While the synthesis of heparan sulfate mimetics is a challenging area, previous research has shown promise in developing similar compounds for various biological applications.
Where this research is happening
-
Glycan Therapeutics Corporation
Raleigh, United States Active
Researchers
- Principal investigator: Su, Guowei — Glycan Therapeutics Corporation
- Study coordinator: Su, Guowei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.