Creating a large database of T cell receptors and their interactions with cancer antigens
MATCHMAKERS - large-scale generation of reactive TCR-pMHC pairs from human NSCLC
This study is looking at how certain immune cells recognize cancer markers, which could help create better treatments for cancer patients using their own immune systems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University College London NIH-funded |
| Lab location | 1 site (London, United Kingdom) |
| Project ID | NIH-11046700 on NIH RePORTER |
What this research studies
This research focuses on understanding how T cell receptors (TCRs) recognize tumor antigens presented by MHC molecules, which is crucial for developing effective immunotherapies for cancer. By leveraging advanced machine learning techniques, the project aims to generate a comprehensive dataset of TCR-pMHC pairs from both human and mouse sources. The research will involve high-throughput methods to match TCRs with their corresponding antigens, ultimately enhancing our ability to predict and design targeted cancer treatments. Patients may benefit from improved immunotherapy options as a result of this work.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-small cell lung cancer who may benefit from targeted immunotherapy.
Not a fit: Patients with other types of cancer or those who do not have a suitable T cell receptor profile may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized immunotherapy treatments for patients with non-small cell lung cancer.
How similar studies have performed: Other research has shown promise in using machine learning to enhance immunotherapy, indicating that this approach could be a significant advancement in cancer treatment.
Where this research is happening
London, United Kingdom
- University College London — London, United Kingdom (Active)
Researchers
- Principal investigator: Quezada, Sergio — University College London
- Study coordinator: Quezada, Sergio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.