Creating a kidney monitoring tool to improve treatment for high blood pressure
Official title: Building a kidney monitoring panel to guide therapy in resistant hypertension
Funded at University of Toledo Health Sci Campus · NIH-10943434 · Data updated 2026-11-12
This study is looking to create a simple urine test that helps doctors tell the difference between normal kidney changes and serious kidney problems in people who have high blood pressure that’s hard to control, so they can provide better treatment and keep your heart healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $651,840 |
| NIH project number | 1R01HL175306-01 |
| Project ID | NIH-10943434 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with resistant hypertension, particularly those with renal artery stenosis who are currently on multiple antihypertensive medications.
✕Less likely to help
Patients who do not have resistant hypertension or those without kidney function concerns may not benefit from this research.
What this research studies
This research aims to develop a urine-based kidney health monitoring panel that helps distinguish between benign changes in kidney function and acute kidney injury during treatment for resistant hypertension. By focusing on patients who struggle to control their blood pressure despite using multiple medications, the study seeks to improve treatment outcomes and reduce the risk of cardiovascular complications. The approach involves identifying specific biomarkers that can predict blood pressure responses and kidney health, ultimately guiding therapy decisions. Patients will be monitored closely to ensure that effective hypertension medications can be continued safely.
Why it matters
Potential benefit: If successful, this research could lead to more effective management of resistant hypertension, reducing the risk of serious cardiovascular events and improving overall kidney health.
How similar studies have gone: Other research has shown promise in using biomarker panels for kidney health monitoring, suggesting that this approach could be effective in improving hypertension treatment outcomes.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Gupta, Rajesh — University of Toledo Health Sci Campus
- Study coordinator: Gupta, Rajesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.