Creating a human spinal model to understand the causes of Spina Bifida.
Development of in vitro human spinal neural tube model to study genetic and environmental etiology of Spina Bifida.
This study is looking at how genes and the environment can cause Spina Bifida by creating a 3D model of the spinal area using special stem cells, which will help us understand this condition better and find ways to prevent it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-10952832 on NIH RePORTER |
What this research studies
This research focuses on developing a three-dimensional model of the human spinal neural tube to investigate how genetic and environmental factors contribute to Spina Bifida, a common birth defect. By using human induced pluripotent stem cells, the researchers aim to recreate the conditions that lead to this condition, allowing for a better understanding of its etiology. The study will also involve creating a bioengineered model that mimics the human spinal environment, which could provide insights into how certain genes and environmental exposures interact during development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Spina Bifida or those who are pregnant and concerned about the risk of this condition.
Not a fit: Patients who do not have a genetic predisposition to Spina Bifida or who are not currently pregnant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and treatments for Spina Bifida.
How similar studies have performed: Previous research has shown promise in using similar in vitro models to study other congenital defects, indicating potential for success in this approach.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Kim, Sung Eun — University of Texas at Austin
- Study coordinator: Kim, Sung Eun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.