Creating a human model to study overdose treatments and their effects on multiple organs
Multi-organ human-on-a-chip system to address overdose and acute and chronic efficacy and off-target toxicity
['FUNDING_OTHER'] · UNIVERSITY OF CENTRAL FLORIDA · NIH-10351973
This study is creating a special system that mimics how different organs in the body react to pain medications like fentanyl and morphine, so we can learn more about how effective overdose treatments like Naloxone are and how they might affect the heart, kidneys, and liver, while also looking at how men and women might respond differently.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CENTRAL FLORIDA (nih funded) |
| Locations | 1 site (ORLANDO, UNITED STATES) |
| Trial ID | NIH-10351973 on ClinicalTrials.gov |
What this research studies
This research aims to develop a multi-organ human-on-a-chip system to better understand the effects of overdose treatments for pain medications like fentanyl and morphine. By using human cells, the system simulates how these drugs affect various organs over time, allowing researchers to evaluate both the effectiveness of treatments like Naloxone and any potential toxic effects on the heart, kidneys, and liver. The study will also consider differences between male and female responses to overdose and treatment, providing a more comprehensive understanding of how these drugs work in the body. This innovative approach could lead to improved treatment strategies for patients experiencing overdose.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced opioid overdose or are at risk of overdose due to pain medication use.
Not a fit: Patients who do not use opioid medications or have no history of overdose may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective overdose treatments and better safety profiles for pain medications.
How similar studies have performed: While the approach of using a multi-organ human-on-a-chip system is innovative, similar models have shown promise in other areas of drug testing and toxicity assessment.
Where this research is happening
ORLANDO, UNITED STATES
- UNIVERSITY OF CENTRAL FLORIDA — ORLANDO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HICKMAN, JAMES J — UNIVERSITY OF CENTRAL FLORIDA
- Study coordinator: HICKMAN, JAMES J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.