Creating a human model to study brain and blood vessel interactions in Alzheimer's disease-related dementias.
Official title: Human iPSC model of Cerebro-Vascular Interactions in ADRD
Funded at Regenerative Research Foundation · NIH-10973050 · Data updated 2026-11-12
This study is creating a special 3D model using human cells to help us understand how brain cells and blood vessels work together in Alzheimer's disease, which could lead to better insights and treatments for people affected by this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Regenerative Research Foundation NIH-funded |
| Lab location | 1 site (Albany, UNITED STATES) |
| Project start | August 15, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,931,965 |
| NIH project number | 1R61NS138655-01 |
| Project ID | NIH-10973050 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with non-neurological conditions or those not affected by Alzheimer's disease or related dementias may not receive any benefit from this research.
What this research studies
This research aims to develop a sophisticated model using human cells to better understand how brain cells and blood vessels interact in Alzheimer's disease-related dementias (ADRD). By utilizing human induced pluripotent stem cells (iPSCs), the researchers will create a 3D model that mimics the human brain's structure and function, allowing for more accurate studies of disease mechanisms. The project will focus on optimizing the integration of brain and vascular cells to reflect real human tissue, which could lead to improved insights into ADRD. This model will be validated through various tests to ensure its reliability and relevance to human health.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in developing similar human models for studying neurological diseases, indicating a potential for success in this novel approach.
Where this research is happening
-
Regenerative Research Foundation
Albany, United States Active
Researchers
- Principal investigator: Temple, Sally — Regenerative Research Foundation
- Study coordinator: Temple, Sally
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.