Creating a human cell-based model to study frontotemporal dementia and ALS
A microphysiologic multicellular organ-on-chip to inform clinical trials in FTD/ALS
This study is creating a special model of the brain to help researchers learn more about frontotemporal dementia and ALS, with the hope that it will lead to better treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10849733 on NIH RePORTER |
What this research studies
This research focuses on developing a microphysiologic system that mimics the human brain environment to study frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). By using human induced pluripotent stem cells, the researchers will create a 3D model that includes various brain cell types, such as neurons, astrocytes, and microglia, along with a blood-brain barrier component. This model aims to better understand the interactions between these cells and identify potential biomarkers for these neurodegenerative diseases, ultimately aiding in the design of clinical trials. Patients may benefit from insights gained through this innovative approach, which could lead to more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with frontotemporal dementia or amyotrophic lateral sclerosis, particularly those with genetic links to the C9orf72 gene.
Not a fit: Patients with other forms of dementia or neurodegenerative diseases unrelated to FTD or ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the identification of new biomarkers and treatment strategies for patients with FTD and ALS.
How similar studies have performed: Previous research has shown promise in using organ-on-chip technologies to model neurodegenerative diseases, indicating that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Svendsen, Clive Niels — Cedars-Sinai Medical Center
- Study coordinator: Svendsen, Clive Niels
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.