Creating a digital model to predict treatment responses in acute myeloid leukemia.
Official title: Prototype System for AML Digital Twins
Funded at Institute for Systems Biology · NIH-10993608 · Data updated 2026-11-12
This study is working on a new tool that creates a digital version of your acute myeloid leukemia (AML) using your personal health information, so doctors can better understand how you might respond to different treatments and find the best options for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $629,127 |
| NIH project number | 5R01CA270210-03 |
| Project ID | NIH-10993608 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with acute myeloid leukemia, particularly those who have relapsed or are unfit for intensive therapies.
✕Less likely to help
Patients with other types of leukemia or those who are not diagnosed with acute myeloid leukemia may not benefit from this research.
What this research studies
This research aims to develop a prototype system called the AML Digital Twin, which will simulate a patient's unique disease characteristics using their clinical and molecular data. By creating a digital representation of the patient's acute myeloid leukemia (AML), doctors can explore personalized predictions of how the patient might respond to various treatments. This approach allows for a more tailored treatment plan, potentially improving outcomes for patients who have limited options due to the nature of their disease. The system will utilize data from bone marrow aspirates and blood samples to inform the simulations.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for patients with acute myeloid leukemia.
How similar studies have gone: While the concept of Digital Twins is gaining traction in various fields, this specific application in acute myeloid leukemia is novel and has not been extensively tested in clinical settings.
Where this research is happening
-
Institute for Systems Biology
Seattle, United States Active
Researchers
- Principal investigator: Thorsson, Vesteinn — Institute for Systems Biology
- Study coordinator: Thorsson, Vesteinn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.