Creating a device to study opioid addiction and pain management.
Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.
This study is creating a special device that acts like human organs to help researchers learn more about opioid addiction and chronic pain, so they can find better treatments for people struggling with these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10904889 on NIH RePORTER |
What this research studies
This research focuses on developing a multi-organ-on-chip device that mimics human biological systems to better understand opioid addiction and withdrawal, as well as chronic pain. By using human cells, the researchers aim to create a high-throughput model that can screen potential therapeutic drugs for opioid use disorder and non-addictive pain treatments. The device will incorporate various brain and liver components to study the neurobiology of addiction and pain, providing insights into the mechanisms that drive these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from opioid use disorder or chronic pain who are seeking alternative treatment options.
Not a fit: Patients who are not affected by opioid use disorder or chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for opioid use disorder and chronic pain that do not carry the risk of addiction.
How similar studies have performed: Previous research has shown promise in using organ-on-chip technologies for drug screening and understanding complex biological interactions, indicating a potential for success in this novel approach.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Maidment, Nigel T — University of California Los Angeles
- Study coordinator: Maidment, Nigel T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.