Creating a device that automatically delivers naloxone to prevent opioid overdoses
Development of an implantable closed-loop system for delivery of naloxone for the prevention of opioid-related overdose deaths
This study is testing a new device that can automatically detect if someone is having an opioid overdose and give them a life-saving medication called naloxone, so it’s especially for people who have used opioids and might need help in an emergency.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10456452 on NIH RePORTER |
What this research studies
This research focuses on developing an innovative implantable device that can detect an opioid overdose and automatically administer naloxone, a life-saving medication. The device aims to eliminate the need for immediate intervention by others, which is crucial during an overdose situation. By continuously monitoring the patient's condition, it can provide timely treatment and alert emergency responders, potentially saving lives. This approach addresses the urgent need for effective overdose prevention methods, especially for individuals with a history of opioid use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of opioid use who are at risk of overdose, particularly those who have recently undergone a period of sobriety.
Not a fit: Patients who do not have a history of opioid use or those who are not at risk of overdose may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the number of opioid-related overdose deaths by providing immediate treatment without the need for external assistance.
How similar studies have performed: While the concept of automated overdose prevention is innovative, similar approaches in drug delivery systems have shown promise in other medical applications, suggesting potential for success in this area.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Gereau, Robert W — Washington University
- Study coordinator: Gereau, Robert W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.