Creating a detailed map of the brain's superficial white matter using advanced MRI techniques
Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRI
This study is creating a detailed map of the brain's surface connections to help us better understand how different parts of the brain work together, which could lead to new insights for people with conditions like Alzheimer's, autism, and bipolar disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11080245 on NIH RePORTER |
What this research studies
This research aims to develop the first comprehensive atlas of the human brain's superficial white matter (SWM) using ultra high resolution diffusion MRI. By addressing the challenges of mapping this critical area, which is involved in neurodevelopment and various neurological disorders, the project seeks to enhance our understanding of brain connectivity. The study will utilize advanced imaging techniques to trace the intricate u-fibers that connect different brain regions, which have been largely overlooked in previous research. This work could provide valuable insights into conditions such as Alzheimer's disease, autism spectrum disorder, and bipolar disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, autism spectrum disorder, bipolar disorder, or other related neurological conditions.
Not a fit: Patients with conditions unrelated to brain connectivity or those who do not have neurological or psychiatric disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for neurological and psychiatric disorders.
How similar studies have performed: While there has been significant research on brain connectivity, this specific approach to mapping the superficial white matter is novel and has not been extensively tested.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: O'donnell, Lauren Jean — Brigham and Women's Hospital
- Study coordinator: O'donnell, Lauren Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.