Creating a detailed brain atlas to understand cell interactions
Official title: Towards an integrated analytics solution to creating a spatially-resolved single-cell multi-omics brain atlas
Funded at Icahn School of Medicine at Mount Sinai · NIH-10724843 · Data updated 2026-11-12
This study is working on creating a detailed map of the human brain to understand how different brain cells talk to each other, especially as we grow older or when facing mental health challenges, which could help find new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 28, 2023 |
| Project end | August 27, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,576,654 |
| NIH project number | 1RF1MH133703-01 |
| Project ID | NIH-10724843 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing neuropsychiatric disorders or age-related cognitive issues.
✕Less likely to help
Patients with acute neurological injuries or those not affected by neuropsychiatric conditions may not receive direct benefits from this research.
What this research studies
This research aims to develop a comprehensive atlas of the human brain that maps out how different types of cells interact with each other. By using advanced technologies to analyze gene expression at a high spatial resolution, the project will explore how these interactions change during brain development, aging, and various neuropsychiatric disorders. Patients can benefit from this research as it seeks to uncover the underlying mechanisms of brain function and dysfunction, potentially leading to new therapeutic strategies. The approach involves integrating various types of biological data to create a detailed picture of cellular communication in the brain.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating neuropsychiatric disorders and age-related cognitive decline.
How similar studies have gone: Other research initiatives, particularly those under the NIH BRAIN Initiative, have shown promising results using similar spatial transcriptomics approaches.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Yuan, Guo-Cheng — Icahn School of Medicine at Mount Sinai
- Study coordinator: Yuan, Guo-Cheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.