Creating a detailed 3D map of the mouse brain using advanced imaging techniques
Official title: A Highly Multiplexed, Multiomic 3D Mouse Brain Map Using MALDI-IHC
Funded at Ambergen, INC · NIH-10705203 · Data updated 2026-11-12
This study is testing a new imaging technique to create a detailed 3D map of the mouse brain, which could help us better understand how the brain works and how diseases like Alzheimer's affect it.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ambergen, INC NIH-funded |
| Lab location | 1 site (Watertown, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $910,446 |
| NIH project number | 5R44MH132196-02 |
| Project ID | NIH-10705203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodegenerative disorders or those interested in the underlying mechanisms of brain function.
✕Less likely to help
Patients with acute brain injuries or those not affected by neurodegenerative conditions may not benefit from this research.
What this research studies
This research focuses on developing a new imaging technology called MALDI-IHC to create a highly detailed 3D molecular map of the mouse brain. By using innovative mass-tags linked to specific antibodies, the study aims to identify and visualize thousands of biomolecules that are crucial for understanding brain function and diseases. This approach allows for a more comprehensive analysis of the brain's molecular composition compared to traditional imaging methods. The findings could provide valuable insights into neurodegenerative disorders and other brain-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain function and the development of new treatments for neurodegenerative diseases.
How similar studies have gone: Other research has shown success with advanced imaging techniques, but the specific approach of MALDI-IHC is relatively novel and untested in this context.
Where this research is happening
-
Ambergen, INC
Watertown, United States Active
Researchers
- Principal investigator: Lim, Mark — Ambergen, INC
- Study coordinator: Lim, Mark
Related research
Other NIH-funded projects on the same topics.
-
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This study is working on a new way to closely examine how your immune system responds to COVID-19, including how vaccines help and what happens with long-COVID, so that doctors can provide better, more personalized care for patients like you.
-
Using advanced imaging techniques to study Alzheimer's disease brain tissue.
This study is exploring new ways to take detailed pictures of brain tissue affected by Alzheimer's disease to better understand how the disease works, which could lead to better ways to diagnose and treat patients in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.