Creating a detailed 3D map of the mouse brain using advanced imaging techniques
A Highly Multiplexed, Multiomic 3D Mouse Brain Map Using MALDI-IHC
This study is testing a new imaging technique to create a detailed 3D map of the mouse brain, which could help us better understand how the brain works and how diseases like Alzheimer's affect it.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ambergen, INC NIH-funded |
| Lab location | 1 site (Watertown, United States) |
| Project ID | NIH-10705203 on NIH RePORTER |
What this research studies
This research focuses on developing a new imaging technology called MALDI-IHC to create a highly detailed 3D molecular map of the mouse brain. By using innovative mass-tags linked to specific antibodies, the study aims to identify and visualize thousands of biomolecules that are crucial for understanding brain function and diseases. This approach allows for a more comprehensive analysis of the brain's molecular composition compared to traditional imaging methods. The findings could provide valuable insights into neurodegenerative disorders and other brain-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative disorders or those interested in the underlying mechanisms of brain function.
Not a fit: Patients with acute brain injuries or those not affected by neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain function and the development of new treatments for neurodegenerative diseases.
How similar studies have performed: Other research has shown success with advanced imaging techniques, but the specific approach of MALDI-IHC is relatively novel and untested in this context.
Where this research is happening
Watertown, United States
- Ambergen, INC — Watertown, United States (Active)
Researchers
- Principal investigator: Lim, Mark — Ambergen, INC
- Study coordinator: Lim, Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.