Creating a detailed 3D map of the human liver
Multimodal mass spectrometry imaging of mouse and human liver
['FUNDING_OTHER'] · COLUMBIA UNIV NEW YORK MORNINGSIDE · NIH-10817566
This study is creating a detailed 3D map of the liver to help us understand how its structure changes when we're healthy or sick, which could lead to better ways to diagnose and treat liver problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIV NEW YORK MORNINGSIDE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10817566 on ClinicalTrials.gov |
What this research studies
This research aims to develop the first-ever spatially-resolved 3D map of the human liver, which will integrate cellular components, metabolites, and the extracellular matrix. By utilizing advanced mass spectrometry imaging techniques, the team will analyze the liver's architecture at an unprecedented level of detail. This project is a collaborative effort involving multiple prestigious institutions, focusing on understanding how the liver's structure changes in health and disease. The findings could provide insights into liver function and disease mechanisms, potentially leading to improved diagnostic and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with liver diseases, such as hepatocellular carcinoma or other liver disorders.
Not a fit: Patients with healthy liver function or those without any liver-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of liver diseases and lead to better treatment options for patients with liver conditions.
How similar studies have performed: Other research has shown success in mapping organ structures using similar advanced imaging techniques, indicating a promising approach for this project.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIV NEW YORK MORNINGSIDE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STOCKWELL, BRENT R. — COLUMBIA UNIV NEW YORK MORNINGSIDE
- Study coordinator: STOCKWELL, BRENT R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.