Creating a detailed 3D map of the human hippocampus for understanding neurological disorders
Imaging platform and computational HARDI atlas of the human hippocampus
This study is creating a detailed 3D map of a part of the brain called the hippocampus, which is important for understanding conditions like Alzheimer's, epilepsy, and schizophrenia, to help improve diagnosis and treatment for people with these neurological disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10385806 on NIH RePORTER |
What this research studies
This research focuses on developing a three-dimensional imaging atlas of the human hippocampus, which is crucial for understanding various neurological disorders, including Alzheimer's disease. By utilizing advanced diffusion MRI techniques, the project aims to map the intricate organization and connectivity of the hippocampus, which is often affected in conditions like epilepsy and schizophrenia. The atlas will provide unprecedented detail about the microstructure of the hippocampus, enhancing our understanding of how these regions are impacted by disease. This innovative approach could lead to better diagnostic and therapeutic strategies for patients with neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or other related neurological disorders.
Not a fit: Patients with neurological conditions not involving the hippocampus may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment options for patients suffering from Alzheimer's disease and other neurological conditions.
How similar studies have performed: Previous research has shown success in using advanced imaging techniques to map brain structures, indicating a promising potential for this novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Aggarwal, Manisha — Johns Hopkins University
- Study coordinator: Aggarwal, Manisha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.